Post-Transplant Lymphoproliferative Disorder of the Brain Mimics Brain Abscess: Case Report and Review Literature: Post-Transplant Lymphoproliferative Disorder of the Brain Mimics Brain Abscess: Case Report and Review Literature

Wiboon Suriyajakryuththana; Pat Suntarawipath  Kwankaew; Noppadol larbcharoensub

doi:10.46475/asean-jr.v18i1.1000

Authors

Wiboon Suriyajakryuththana, M.D. 1Departments of Radiology , Faculty of Medicine Ramathibodi Hospital, Mahidol University, Thailand.
Pat Suntarawipath Kwankaew, M.D. Department of Radiology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Thailand.
Noppadol larbcharoensub, M.D. Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Thailand.

DOI:

https://doi.org/10.46475/asean-jr.v18i1.1000

Abstract

Post-transplant lymphoprolferative disorder (PTLD) is a spectrum of hematological diseases aring in
context of immunosuppression after organ transplantation. PTLD can involve any organ. We have studied
two cases of polymorphic PTLD of the brain that developed in patient with relapsed acute lymphoblastic
leukemia (ALL) following two times of bone marrow transplantation ongoing immunosuppressive therapy
and end stage renal disease with renal transplantation. Additionally, case of PTLD in the brain was
reviewed in 2004. The neoplasm showed large cell morphology and B-cell phenotype. In situ hybridion
for Epstein-Barr virus (EBV) was positive. Complete remission was obtained after decreasing immunosup-
pressive therapy. The patient remained in remission at almost 2-years' follow up. This rare case increased
our awareness of PTLD in the brain of patients following organ transplantation and immunosuppressive
therapy.

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and Disclosures Published: 03/31/2000

Post-Transplant Lymphoproliferative Disorder of the Brain Mimics Brain Abscess: Case Report and Review Literature