DETECTION OF ACUTE CEREBRAL ISCHEMIA WITH Tc-99m APCITIDE SCINTIGRAPHY

Authors

  • Supatporn TEPMONGKOL Faculty of Medicine, Chulalongkorn University

Keywords:

stroke, platelet membrane glycoprotein (complex IIB-IITA), radionuclide imaging

Abstract

The established indication of Tc-99m apcitide scintigraphy is to detect deep venous thrombosis. However, due to its mechanism of binding to GP IIb/IIla receptor on activated platelet, imaging of acute cerebral thrombosis is possible. This is a case report of acute ischemic stroke patient with right leg swelling who was referred to have Tc-99m apcitide scintigraphy for diagnosis of deep venous thrombosis. The scan showed no abnormal uptake in both legs but, interestingly, uptake in the left parieto-occipital region. This corresponds to clinical and the computer tomographic finding of acute ischemic stroke in the same area. With the use of Tc-99m apcitide scintigraphy, the area of acute cerebral ischemia and its causes can be synchronously identified. Various causes of progressing stroke may also be differentiated at the same time as well.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

AcutectTM Prescribing Information

Becker RC (1996). Antiplatelet therapy. Science&Medicine July/August: 12-21

Muto P, Lastoria S, Varella P, Vergara E, Salvatore M, Morgano G, Lister-James J, Bernardy JD, Dean RT, Wencker D, Borer JS (1995) Detecting deep venous thrombosis with Technetium-99m labeled synthetic peptide P280. J Nucl Med 36(8): 1384-1391

Lister-James J, Knight LC, Maurer AH, Bush Lr, Moyer BR, Dean RT (1996) Thrombus imaging with a_technetium- 99m-labeled, activated platelet receptorbinding peptide. J Nucl Med 37(5): 775- 781

Dodd LR, Krishnamurthy GT, Kreis JM, Walsh TK , Shah JH (1996) Detection of acute deep venous thrombosis (DVT) by scintigraphy with Tc-99m P280, a synthetic peptide that binds to glycoprotein Ilb/IIla receptors on activated platelets. J Nucl Med 37(5S):95P-96P. Abstract

Weiland FL, Obranovich GT, Vande Streek PR, Carretta RF (1996) Technetium-99m P280 labeled peptide in the detection and localization of deep vein thrombosis: a prospective study in 32 cases. J Nucl Med 37(5S):294P. Abstract

Taillefer R, Therasse E, Turpin §S, Lambert R, Robillard P, Soulez G (1999) Comparison of early and delayed scintigraphy with 99mTc-Apcitide and correlation with contrast-enhanced venography in detection of acute deep vein thrombosis. J Nucl Med 40:2029-2035

Pearson DA, Lister-James, McBride WJ, Wilson DM, Martel LJ, Civitello ER, Dean RT (1996) Thrombus imaging using technetium-99m-labeled high potency GPIIb/IIIa receptor antagonists. Chemistry and initial biologic studies. J Med Chem 39(7):1372-1382

Vallabhajosula S, Weinberger J, Machac J, Lister-James J, Dean RT, Lipszye H, Patel SL, Harrington E, Harrington M (1996) Technetium-99m P280, activated platelet specific techtideTM. Phase II clinical studies in patients with carotid atherosclerosis. J Nucl Med 37:272P. Abstract

Muto P. Lastoria S, Varella P, Acampa W, Vergara E, Mainolfi C, Spaziante R, Ferone D, Bernardy JD, Salvatore M (1994) Brain tumors imaging with Tc-99m labeled synthetic peptide P280. EurJ Nucl Med 21:S198. Abstract

Lastoria S, Muto P, Varella P, Vergara E, Mainolfi C, Spaziante R, Bernardy JD, Goldsmith SJ, Salvatore M (1994) Localization of human brain tumors by Tc-99m labelled P-280 synthetic peptide. J Nucl Med 35:97P. Abstract

Dougherty JH, Jr, Levy DE, Weksler BB (1977) Platelet activation in acute cerebral ischemia. Lancet 1:821-824

Millikan CH, McDowell FH (1981) Treatment of progressing stroke. Stroke 12:397-409

Katzman R, Clasen R, Klatzo I, Meyer JS, Pappius HM, Waltz AG (1977) Report of joint committee for stroke resources IV. Brain edema in stroke. Stroke 8:512-540

Hachinski V, Norris JW (1985) The deteriorating stroke. In: Hachinski V, Norris JW (eds) The acute stroke. F.A. Davis F.A. Davis, Philadelphia, pp 123- 140

Tsuda T, Kubota M, Iwakubo A, Akiba H, Shido M, Takahashi T, Nakata T, Noto T, Tanaka S, limura O (1989) Availability of 111In-labeled platelet scintigraphy in patients with — postinfarction _ left ventricular aneurysm. Ann Nucl Med 3(1): 15-24.

Downloads

Published

2023-04-13

How to Cite

1.
TEPMONGKOL S. DETECTION OF ACUTE CEREBRAL ISCHEMIA WITH Tc-99m APCITIDE SCINTIGRAPHY. ASEAN J Radiol [Internet]. 2023 Apr. 13 [cited 2024 Dec. 9];8(1):73-6. Available from: https://www.asean-journal-radiology.org/index.php/ajr/article/view/593

Issue

Section

Original Article

Similar Articles

1 2 3 4 5 6 7 8 9 10 > >> 

You may also start an advanced similarity search for this article.