DIAGNOSIS OF PARATHYROID ADENOMA USING TECHNETIUM-99m-SESTAMIBI IMAGING

Authors

  • Molrudee EKMAHACHAI Department of Radiology
  • Wannee OJARUSPORN Department of Radiology
  • Sombut BOONYAPRAPA Department of Radiology
  • Kamthorn THAMPRASERT Department of Pathology, Faculty of Medicine, Chiang Mai University

Abstract

A 24-year-old female was referred for Technetium-99m-Sestamibi (99m Tc-MIBI) parathyroid imaging, due to highly suspected of primary hyperparathyroidism from the clinical and biochemical findings. The early 99m Tc-MIBI parathyroid imaging clearly demonstrated a focal increased uptake located just inferior to the left lobe of thyroid gland and the lesion showed significantly increased uptake on late imaging at 2 hours after 99m Tc-MIBI injection, in contrast to the gradually decreased uptake of the normal thyroid tissue. The scintigraphic findings were typical for left parathyroid adenoma. Surgical finding and histopathologic examination also confirmed the diagnosis of the left parathyroid adenoma.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Potts JT Jr. Diseases of the parathyroid gland and other hyper- and hypocalcemic disorders. In: Wilson JD, eds. Harrison's principles of internal medicine. 12th ed. McGraw-Hill, 1991: 1902-6.

Fine EJ. Parathyroid imaging: Its current status and future role. Semin Nucl Med 1987;17:350-9.

Gooding GAW, Oker lund MD, Stark DD. Parathyroid imaging: comparison of double-tracer (Tl-201, Tc-99m) scintigraphy and high-resolution US. Radiology 1986;161:57-64.

Stark DD, Gooding GAW, Moss AA, et al. Parathyroid imaging: comparison of high-resolution

CT and high-resolution sonography. AJR 1983; 141:633-8.

Spritzer CE, Gefter WB, Hamilton R, et al. Abnormal parathyroid glands: high-resolution MR imaging. Radiology 1987; 162:487-91.

Eisenberg H, Pallotta J, Sherwood LM. Selective arteriography, venography and venous hormone assay in diagnosis and localization of parathyroid lesions. Am J Med 1974;56:810-20.

Picard D, D'Amour P, Carrier L, et al. Localization of abnormal parathyroid gland(s) using thallium- 201/iodine-123 subtraction scintigraphy in patients with primary hyperparathyroidism. Clin Nucl Med 1987;12:60-4.

Ferlin G, Borsato N, Camerani M, et al. New perspectives in localizing enlarged parathyroids by technetium-thallium subtraction scan. J Nucl Med 1983;24:438-41.

Young AE, Gaunt JI, Croft DN, et al. Location of parathyroid adenomas by thallium-201 and technetium-99m subtraction scanning. Br Med J 1983;286:1384-6.

Percival RC, Blake GH, Urwin GH, et al. Assessment of thallium pertechnetate subtraction scintigraphy in hyperparathyroidism. Br J Radiol 1985;58:131-5.

Coakley AJ, Kettle AG, Wells CP, et al. Technetium-99m-sestamibi-a new agent for parathyroid imaging. Nucl Med Commun 1989; 10:791-4.

Wackers FJ, Berman DJ, Maddahi J, et al. Technetium-99m-hexakis-2-methoxyisobutyl isonitrile: human biodistribution, dosimetry, safety and preliminary comparison to thallium-201 for myocardial perfusion imaging. J Nucl Med 1989; 30:301-11.

Taillefer R, Boucher Y, Potvin C, et al. Detection and localization of parathyroid adenomas in patients with hyperparathyroidism using a single radionuclide imaging procedure with Technetium- 99m-Sestamibi (double-phase study). J Nucl Med 1992;33:1801-7.

O'Doherty MJ, Kettle AG, Wells CP, et al. Parathyroid imaging with technetium-99m-sestamibi: preoperative localization and tissue uptake studies. J nucl Med 1992;33:313-8.

Wei JP, Burke GJ, Mansberger AR Jr. Prospective evaluation of the efficacy of technetium-99m sestamibi and iodine-123 radionuclide imaging of abnormal parathyroid glands. Surg 1992;112:1111-7.

Casas AT, Burke GJ, Sathyanarayana, et al. Prospective comparison of Technetium-99m- Sestamibi/Iodine-123 radionuclide scan versus high-resolution ultrasonography for the preoperative localization of abnormal glands in patients with previously unoperated primary hyperparathyroidism. Am J Surg 1993;166:369-73.

Weber CJ. Vansant J, Alazraki N, et al. Value of technetium-99m sestamibi iodine-123 imaging in preoperative parathyroid surgery. Surg 1993;114:1011-8.

Neumann DR, Esselstyn CB, Eastwood J, et al. Localization of mediastinal parathyroid adenoma in recurrent postoperative hyperparathyroidism with Tc-99m Sestamibi SPECT. Clin Nucl Med 1995;20:175.

Aurbach GD, Marx SJ, Spiegel AM. Parathyroid hormone, calcitonin and the calciferols. In: Wilson JD, Foster DW, eds. Textbook of endocrinology. 7th ed. W.B.Saunders company, 1985:1170-6.

Benard F, Lefebvre B, Beuvon F, et al. Rapid washout of Technetium-99m-MIBI from a large parathyroid adenoma. J Nucl Med 1995;36:241-3.

Downloads

Published

2023-03-30

How to Cite

1.
EKMAHACHAI M, OJARUSPORN W, BOONYAPRAPA S, THAMPRASERT K. DIAGNOSIS OF PARATHYROID ADENOMA USING TECHNETIUM-99m-SESTAMIBI IMAGING. ASEAN J Radiol [Internet]. 2023 Mar. 30 [cited 2024 Dec. 9];1(3):9-13. Available from: https://www.asean-journal-radiology.org/index.php/ajr/article/view/257

Issue

Section

Original Article