DIAGNOSIS OF HEPATIC CAVERNOUS HEMANGIOMA USING TECHNETIUM-99M RED BLOOD CELL IMAGING
Abstract
Thirty-one patients with various focal hepatic lesions suspected of hepatic cavernous hemangiomas (HCHs) on liver ultrasonography(US) and/or computed tomography (CT) were evaluated by Technetium-99m red blood cell imagings. All patients were studied with blood- flow and sequential planar blood-pool images. Additional single-photon emission CT (SPECT) images were also performed in 19 patients. Twenty-five patients with scinti-graphic charac- teristic of HCH were diagnosed as HCH, 5 proven by angiography and 20 proven by main- taining a stable clinical course ranging from 6 to 24 months with the absence of any signs and symptoms of a liver malignancy, either primary or metastatic disease. All except 3 patients with a history of hepatitis B or C virus carrier had completely normal liver function tests. Six of 25 hemangioma patients had multiple lesions. Twenty-two cases of HCHs were clearly diagnosed by planar imagings and the other 3 patients needed SPECT imagings for diagnosis of HCHS. The remaining 6 patients, 4 had a final diagnosis as hepatoma proven by angiography and liver biopsy, and the other 2 patients were diagnosed as liver metastases proven by follow-up clinical course and liver US study.
Downloads
Metrics
References
Ishak KG, Rabin L. Benign tumors of the liver. Med Clin North Am 1975; 59: 995-1013.
Adam YG, Huvos AG, Fortner JG. Giant heman- giomas of the liver. Ann Surg 1970; 172: 239- 245.
Moinuddin M, Allison JR, Montgomery JH, et al. Scintigraphic diagnosis of hepatic hemangioma: Its role in the management of hepatic mass le sions. AJR 1985; 145:223-228.
Itai Y, Ohtomo K, Araki T, et al. Computed tomography and sonography of cavernous heman- gioma of the liver. AJR 1983; 141: 315-320.
Gibney RG, Hendin AP, Cooperberg PL.Sono- graphically detected hepatic hemangiomas: absence of change over time. AJR 1987; 149: 953-957.
Lisbona R, Derbekyan V, Novales-Diaz JA, et al. Scintigraphic and ultrasound features of giant hemangiomas of the liver. J Nucl Med 1989; 30: 181-186.
Jacobson AF, Teefey SA. Cavernousheman- giomas of the liver: association of sonographic appearance and results of Tc-99m labeled red blood cell SPECT. Clin Nucl Med 1994; 19:96-99.
Nelson RC, Chezmar JL. Diagnostic approach to hepatic hemangiomas. Radiology 1990; 176: 11-13.
Brant WE, Floyd JL, Jackson DE, et al. The radiological evaluation of hepatic cavernous hemangioma. JAMA 1987; 257: 2471-2474.
Bree RL, Schwab RE, Glazer GM, et al. The varied appearances of hepatic cavernous heman- giomas with sonography, computed tomography, magnetic resonance imaging and scintigraphy. Radio Graphics 1987; 7: 1153-1174.
Freeny PC, Marks WM. Hepatic hemangioma: dynamic bolus CT. AJR 1986; 147:711-719.
Itoh K, Saini S, Hahn PF, et al. Differentiation between small hepatic hemangiomas and meta- stases on MR images: importance of size-speci- fic quantitative criteria. AJR 1990; 155: 61-66.
Birnbaum BA, Weinreb JC, Megibow AJ, et al. Definitive diagnosis of hepatic hemangiomas: MR imaging versus Tc-99m-labeled red blood cell SPECT. Radiology 1990; 176: 95-101.
Brown RKJ, Gomes A, King W, et al. Hepatic hemangiomas:Evaluation bymagnetic resonance imaging and technetium-99m red blood cell scintigraphy. J Nucl Med 1987; 28: 1683-1687.
Larcos G, Farlow DC, Gruenewald SM, et al. A typical appearance of a hepatic hemangioma with technetium-99m-red blood cell scintigraphy. J Nucl Med 1989; 30:1885-1888.
Intenzo C, Kim S, Madsen M, et al. Planar and SPECT Tc-99m red blood cell imaging in he patic cavernous hemangiomas and other hepatic lesions. Clin Nucl Med 1988; 13:237-240.
Rabinowitz SA, McKusick KA, Strauss HW.99mTc-red blood cell scintigraphy in evalua- ting focal liver lesions. AJR 1984; 143: 63-68.
Front D, Royal HD, Israel O, et al. Scintigraphy of hepatic hemangiomas: The value of Tc-99m- labeled red blood cells: Concise communication. J Nucl Med 1981; 22:684-687.
Engel MA, Marks DS, Sandler MA, et al. Dif- ferentiation of focal intrahepatic lesions with 99mTc-red blood cell imaging. Radiology 1983; 146: 777-782.
Brodsky RI, Friedman AC, Maurer AH, et al. Hepatic cavernous hemangioma: Diagnosis with 99mTc-labeled red cells and single photon emis- sion CT. AJR 1987; 148: 125-129.
Kim SM, Park CH, Yang SL, et al. Pathogno- monic scintigraphic finding of hepatic cavernous hemangioma. Clin Nucl Med 1987; 12: 53-54.
Alavi A, Rubin RA, Lichtenstein GR. Scinti- graphic evaluation of liver masses: cavernous hepatic hemangioma. J Nucl Med 1993; 34: 849-852.
Trastek VF, Van Heerden JA, Sheedy PF, et al. Cavernous hemangiomas of the liver: Resect or observed?. Amer J Surg 1983; 145: 49-53.
Callahan RJ, Froelich JW, McKusick KA, et al. A modified method for the in vivo labeling of red blood cells with Tc-99m: concise commu- nication. J Nucl Med 1982; 23: 315-318.
Kudo M, Ikekubo K, Yamamoto K, et al. Dis- tinction between hemangioma of the liver and hepatocellular carcinoma: Value of labeled RBC- SPECT scanning. AJR 1989: 152; 977-983.
Ginsberg F, Slavin JD, Spencer RP. Hepatic angiosarcoma: mimicking of angioma on three- phase technetium-99m-red blood cell scinti- graphy. J Nucl Med 1986; 27: 1861-1863.
Guze BH, Hawkins RA. Utility of the SPECT Tc-99m labeled RBC blood pool scan in the detection of hepatic hemangiomas. Clin Nucl Med 1989; 14: 817-818.
Malik MH. Blood-pool SPECT and planar imaging in hepatic hemangioma. Clin Nucl Med 1987; 12: 543-547.
Ziessman HA, Silverman PM, Patterson J, et al. Improved detection of small cavernous hemangiomas of the liver with high-resolution three-headed SPECT. J Nucl Med 1991; 32: 2086-2091.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 The ASEAN Journal of Radiology
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Disclosure Forms and Copyright Agreements
All authors listed on the manuscript must complete both the electronic copyright agreement. (in the case of acceptance)
